In this post, we discuss a publication in Nature Cell Biology, titled ‘Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer’ The paper can be accessed here. As we age, parts of our body become less functional. The same applies at the level of individual immune cells. T cells in our body are less likely to react to foreign … Continue reading Re-fuelling tired immune cells to fight tumour
A publication in Science Immunology, titled ‘FOXP3 exon 2 controls Treg stability and autoimmunity’, explores how Foxp3 gene might function. The paper can be accessed here. Background The regulatory T cells (Tregs) are an important immune cell that suppresses other immune cells. They are important for suppressing activation of immune cells against our own body. A gene called Foxp3 is critical for the function and … Continue reading Exon 2 of Foxp3 controls Treg seeding of peripheral tissue, and maybe their stability
In this post, we discuss a publication in Nature Immunology, titled ‘Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche’. The paper can be accessed here. This paper examines the role of regulatory T cells (Tregs). Tregs are a subset of immune cells that are known for its ability to control and suppress other immune cells. Their function is extremely important … Continue reading Immune cells and stem cells
Bio (Journal) Club 